Dr. Yan Peng | Nanotheranostics | Best Researcher Award
Vice Professor | Fuyang Normal University | China
Dr. Yan Peng is a dynamic molecular genetics researcher whose work centers on genetic testing, RNA imaging, and fluorogenic aptamer technologies. With a growing scholarly footprint reflected in 73 Scopus citations, 7 indexed documents, and an h-index of 5, her research advances innovative molecular tools for visualizing and quantifying RNA and protein interactions in living cellular environments. Her publication portfolio demonstrates a sustained commitment to high-impact research in analytical chemistry, nucleic acid engineering, and functional genomics. Dr. Yan Peng has contributed significantly to the development of RNA-based imaging platforms, notably pioneering strategies for in situ mRNA visualization through split aptamers and protein-based reporters. Her research extends into genetically encoded fluorogenic allosteric aptamers for live-cell RNA tracking, with articles featured in top-tier journals such as Analytical Chemistry, Analytica Chimica Acta, and Nucleic Acids Research. A notable dimension of her work involves the design of organelle-targeted fluorogen-activating aptamers, enabling precise spatial mapping of endogenous RNA molecules within complex biological systems. Additionally, she has collaborated on influential studies exploring RNA-guided PROTAC activation and functional retention in frame-shifted proteins, contributing new insights to the fields of RNA biology and protein engineering. Dr. Yan Peng has secured multiple competitive research grants as Principal Investigator, including national, provincial, and institutional funding supporting advancements in molecular diagnostics, RNA imaging technologies, and interdisciplinary medical research. Her funded projects span initiatives from the Ministry of Education’s Industry–University Collaborative Education Program and several Anhui Province scientific research programs, collectively amounting to substantial support for her expanding research endeavors. Her contributions reflect strong innovation in nucleic acid engineering, live-cell imaging methodologies, and translational molecular technologies. Dr. Yan Peng’s work continues to shape emerging directions in genetic testing, RNA visualization, and molecular analytical systems, establishing her as an influential scholar within the molecular genetics and biomedical research community.
Featured Publications
1. Peng, Y., Ai, X. L., Yuan, Y. Y., Dong, J., Cui, X., Du, F., Huang, X., & Tang, Z. (2022). Organelle-targeted imaging based on fluorogen-activating RNA aptamers in living cells. Analytica Chimica Acta, 1209, 339816. https://doi.org/10.1016/j.aca.2022.339816
2. Peng, Y., Huang, X., Huang, T. F., Du, F., Cui, X., & Tang, Z. (2022). Combining protein and RNA quantification to evaluate promoter activity by using dual-color fluorescent reporting systems. Bioscience Reports, 41(9), BSR20211525. https://doi.org/10.1042/BSR20211525
3. Xu, Y., Fu, D. Q., Yuan, Y., Peng, Y., Dong, J., Du, F., Huang, X., Liu, G. X., Chen, X. H., Wang, Q. W., & Tang, Z. (2023). A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function. Cell Reports Physical Science, 3(10), 101064. https://doi.org/10.1016/j.xcrp.2023.101064
4. Huang, X., Chen, R., Sun, M. L., Peng, Y., Pu, Q. L., Yuan, Y., Chen, G. Y., Dong, J., Du, F., Cui, X., & Tang, Z. (2021). Frame-shifted proteins of a given gene retain the same function. Nucleic Acids Research, 48(8), 4396–4404. https://doi.org/10.1093/nar/gkaa169
5. Huang, X., Zhao, Y. Y., Pu, Q. L., Liu, G. X., Peng, Y., Wang, F., Chen, G. Y., Sun, M. L., Du, F., Cui, X., & Tang, Z. (2020). Intracellular selection of trans-cleaving hammerhead ribozymes. Nucleic Acids Research, 47(5), 2514–2522. https://doi.org/10.1093/nar/gky1191