Angelique Nicolas Messi | Computational Chemistry | Best Researcher Award

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Dr. Angelique Nicolas Messi | Computational Chemistry | Best Researcher Award

Department of Organic Chemistry, University of Yaoundé 1 | Cameroon

Dr. Angelique Nicolas Messi is a distinguished Cameroonian organic chemist and Senior Lecturer at the Department of Organic Chemistry, University of Yaoundé I. He also serves as the Head of the Department of Basic and Applied Fundamental Sciences at the State University of Ebolowa, where he teaches general and organic chemistry, analytical chemistry, thermodynamics, pharmacognosy, and research methodology. Dr. Messi earned his Ph.D. in Organic Chemistry from the University of Yaoundé I in 2018, focusing on the isolation, structural elucidation, and bioassay of biflavonoids from Ochna species. He expanded his expertise as a Postdoctoral Research Fellow at the University of Fribourg in Switzerland under Prof. Christian G. Bochet (2020–2021) and through research visits to the University of Free State, South Africa (2015, 2023). His research centers on pharmaceutical and natural product chemistry, emphasizing drug discovery from natural sources, including biflavonoids, flavonoids, and synthetic analogs with neuroprotective, anticancer, antimalarial, and anti-HIV properties. A prolific researcher and mentor, Dr. Messi has authored numerous peer-reviewed articles in high-impact journals such as Pharmaceutics, Molecular Neurobiology, Chemistry Africa, and Biochemical Systematics and Ecology. His scientific impact is reflected in 122 citations, an h-index of 5, and an i10-index of 4. Renowned for his expertise in chromatographic and spectroscopic techniques such as NMR, LC-MS, and HRESIMS, he has contributed significantly to the discovery of novel bioactive compounds. In recognition of his outstanding contributions, he was honored as the “Best Researcher in Organic Chemistry” in 2025 by the Research Chemistry Awards. Fluent in both French and English, Dr. Messi is an invited speaker at international conferences, a reviewer for leading scientific journals, and a strong advocate for green chemistry and sustainable drug development in Africa.

Profile: Google Scholar | Scopus

Featured Publications

  • Ndongo, J. T., Issa, M. E., Messi, A. N., Ngo Mbing, J., Cuendet, M., & Pegnyemb, D. E. (2015). Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana. Natural Product Research, 29(17), 1684–1687.

  • Messi, A. N., Ngo Mbing, J., Ndongo, J. T., Nyegue, M. A., Tchinda, A. T., Yemeda, F. L., & Pegnyemb, D. E. (2016). Phenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities. Phytochemistry Letters, 17, 119–125.

  • Djova, S. V., Nyegue, M. A., Messi, A. N., Afagnigni, A. D., & Etoa, F. X. (2019). Phytochemical study of aqueous extract of Ochna schweinfurthiana F. Hoffm powder bark and evaluation of their anti-inflammatory, cytotoxic, and genotoxic activities. Evidence-Based Complementary and Alternative Medicine, 2019, 8908343.

  • Messi, A. N., Bonnet, S. L., Owona, B. A., Wilhelm, A., Kamto, E. L. D., Ndongo, J. T., & Pegnyemb, D. E. (2022). In vitro and in silico potential inhibitory effects of new biflavonoids from Ochna rhizomatosa on HIV-1 integrase and Plasmodium falciparum. Pharmaceutics, 14(8), 1701.

  • Owona, B. A., Mary, A., Messi, A. N., Ravichandran, K. A., Mbing, J. N., & Pegnyemb, E. (2025). Biflavonoid methylchamaejasmin and Khaya grandifoliola extract inhibit NLRP3 inflammasome in THP-1 cell model of neuroinflammation. Molecular Neurobiology, 62(2), 1605–1619.

HOSSAM M. HASSAN | Pharmaceutical Sciences | Best Researcher Award

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Prof. Dr. HOSSAM M. HASSAN | Pharmaceutical Sciences | Best Researcher Award

prof.Dr. Hossam M. Hassan , College of Pharmacy, University of Kut,Iraq

Dr. Hossam Mokhtar Hassan 🇪🇬 is an esteemed Associate Professor of Pharmacognosy at Nahda University and Beni-Suef University, Egypt 🧪. With a Ph.D. in Pharmaceutical Sciences and postdoctoral training at UCSD’s Scripps Institute 🌊, his expertise lies in natural product chemistry, marine pharmacognosy, and phytotherapy 🌿. He currently serves as Vice-Dean for Postgraduate Affairs and General Manager of the Central Research Lab at NUB 🧫. A dedicated educator and researcher, he has received multiple accolades 🏆 and remains active in scientific societies, pushing the boundaries of drug discovery from natural and marine sources 🔬.

Professional Profile:

Scopus

🎓 Education & Experience 

🎓 Education:

  • 🧪 Ph.D. in Pharmaceutical Sciences, University of Louisiana & Beni-Suef University, 2010

  • 🌿 M.Sc. in Pharmacognosy, Cairo University, 2006

  • 💊 B.Sc. in Pharmaceutical Sciences (Honors), Cairo University, 2000

  • 🌊 Postdoc at Scripps Institute of Oceanography, UCSD, 2013-2014

💼 Experience:

  • 🏛️ Vice-Dean for Postgraduate Affairs, Faculty of Pharmacy, NUB (2019–Present)

  • 👨‍🏫 Associate Professor, Nahda & Beni-Suef Universities (2016–Present)

  • 🧪 General Manager, Central Research Lab, NUB (2017–Present)

📈 Professional Development 

Dr. Hassan has continually honed his skills through international fellowships and academic training 🧳. He has mastered advanced techniques such as NMR, HPLC, LC/MS, GC/MS, and molecular docking for natural product analysis 🔬🧫. His scientific capabilities span pharmacophore modeling, phytochemistry, and marine bioprospecting 🌊🌱. He has also developed leadership skills as a strategic planning team leader at NUB 🗂️, with training in effective teaching, decision-making, communication, and problem-solving 🎯🗣️. His active memberships in the American Society of Pharmacognosy and the Egyptian Syndicate of Pharmacists reflect his commitment to global scientific communities 🌍📚.

🔍 Research Focus Category 

Dr. Hassan’s research is centered on natural product drug discovery, especially from marine and plant-derived sources 🌊🌿. He isolates bioactive compounds from symbiotic bacteria, fungi, and medicinal plants to explore their pharmacological potential 💊. His work involves biotransformation, chemical derivatization, and 3D-QSAR studies for structure–activity relationships 🧪🧬. His expertise in phytochemistry and marine pharmacognosy contributes to identifying novel therapeutic agents against microbial infections, cancer, and fertility disorders 🔬👨‍⚕️. Integrating cutting-edge analytical and modeling techniques, he aims to harness nature’s biodiversity for modern medicine 🌍🧫.

🏆 Awards & Honors 

  • 🏅 Best Master’s Thesis, Faculty of Pharmacy, Cairo University, 2006

  • 🏆 Armor of Excellence, Egyptian Pharmacists Syndicate, 2007

  • 🏆 Armor of Excellence, Egyptian Pharmacists Syndicate, 2012

  • 🎓 Best Ph.D. Thesis in Pharmacognosy, All Egyptian Pharmacy Faculties, 2012

Publication Top Notes:

1. Pachycladins A–E: Eunicellin-Based Diterpenoids

Hassan HM, Khanfar MA, Elnagar AY, Mohammed R, Shaala LA, Youssef DT, Hifnawy MS, El Sayed KA. Pachycladins A–E, prostate cancer invasion and migration inhibitory Eunicellin-based diterpenoids from the Red Sea soft coral Cladiella pachyclados. J Nat Prod. 2010; 73(5):848–853.
https://doi.org/10.1021/np900858m

🔬 Summary:
This study reports the isolation of five new Eunicellin-based diterpenoids, named Pachycladins A–E, from the Red Sea soft coral Cladiella pachyclados. These compounds were shown to inhibit the migration and invasion of prostate cancer cells, indicating promising anticancer potential through marine natural product chemistry.

2. 3D-QSAR of Semisynthetic Eunicellin Diterpenoids

Hassan HM, Elnagar AY, Khanfar MA, Sallam A, Mohammed R, Shaala LA, Youssef DT, Hifnawy MS, El Sayed KA. Design and 3D-quantitative structure-activity relationship of semisynthetic eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors. Eur J Med Chem. 2011; 46(4):1122–1130.
https://doi.org/10.1016/j.ejmech.2011.01.055

🧪 Summary:
The paper explores the design and synthesis of semisynthetic derivatives of eunicellin-based diterpenoids and develops a 3D-QSAR model to evaluate their anticancer activity. These analogs demonstrated enhanced inhibition of prostate cancer cell migration and invasion, highlighting their potential for further drug development.

3. Semisynthetic Sarcophine Derivatives as Anticancer Agents

Hassan HM, Sallam AA, Mohammed R, Hifnawy MS, Youssef DT, El Sayed KA. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors. Bioorg Med Chem. 2011; 19(16):4928–4934.
https://doi.org/10.1016/j.bmc.2011.06.073

🧬 Summary:
This study details the synthesis of analogues of sarcophine, a marine cembranoid, and evaluates their ability to inhibit migration in prostate and breast cancer cell lines. Several derivatives showed strong bioactivity, offering new leads in anticancer drug discovery.

4. Decorosides A and B: Cytotoxic Flavonoid Glycosides

Mostafa ER, Hossam MH, El-Shaimaa AA, Marcel J, Rainer E. Decorosides A and B, cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum. Nat Prod Commun. 2014; 9(4):473–476.
https://doi.org/10.1177/1934578X1400900408

🌿 Summary:
The article reports the isolation of two new flavonoid glycosides—Decorosides A and B—from Rhododendron decorum. Both compounds exhibited cytotoxic effects, contributing to the growing interest in plant-derived anticancer agents.

5. Salinamide F: A Marine-Derived Depsipeptide Antibiotic

Hossam MH, David D, Kyoung HJ, Richard HE, William F. Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp. J Antibiot. 2015; 68(3):206–210.
https://doi.org/10.1038/ja.2014.127

🧫 Summary:
This paper describes the discovery of Salinamide F, a novel depsipeptide isolated from Streptomyces sp.. The compound functions as a potent inhibitor of bacterial RNA polymerase, demonstrating promise as a new class of antibiotic against resistant bacteria.

6. Bioactivity of Pulicaria undulata Metabolites

Taha AH, Sayed AE-T, Hossam MH, Mona HH. Cytotoxic and antioxidant activities of secondary metabolites from Pulicaria undulata. Int J Pharm Pharm Sci. 2016; 8(9):150–155.
https://innovareacademics.in/journals/index.php/ijpps/article/view/13208

🌼 Summary:
The study investigates secondary metabolites from Pulicaria undulata, demonstrating both cytotoxic and antioxidant activities. It highlights the plant’s potential as a natural source of therapeutic agents targeting oxidative stress and cancer.

Conclusion:

Prof. Dr. Hossam M. Hassan exemplifies the qualities of a Best Researcher Award recipient through:

  • Innovative scientific contributions in natural products and pharmaceutical chemistry,

  • Strategic academic leadership and international collaboration,

  • Sustained impact on public health-oriented drug discovery.

His work not only advances science but also addresses critical global health challenges such as cancer, antibiotic resistance, and oxidative stress disorders.